Dev Med Child Neurol. 2008 May Abstract In cerebral folate deficiency syndrome, the presence of autoantibodies against the folate receptor (FR) explains decreased folate transport to the central nervous system and the clinical response to folinic acid. Autoantibody crossreactivity with milk FR from different species prompted us to test the effect of a milk-free diet.…
Are The Symptoms of Autism Caused by a Treatable Metabolic Syndrome?
https://doi.org/10.1016/j.mito.2017.12.007 Abstract Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis,…
Early Lead Exposure and Risk of ADHD
J Pediatr. 2018 May 8. Objective To investigate the prospective associations between early childhood lead exposure and subsequent risk of attention deficit hyperactivity disorder (ADHD) in childhood and its potential effect modifiers. Study Design We analyzed data from 1479 mother-infant pairs (299 ADHD, 1180 neurotypical) in the Boston Birth Cohort. The child’s first blood lead…
Aluminium in Brain Tissue in Autism
J Trace Elem Med Biol. 2018 Mar;46:76-82 Abstract Autism spectrum disorder is a neurodevelopmental disorder of unknown aetiology. It is suggested to involve both genetic susceptibility and environmental factors including in the latter environmental toxins. Human exposure to the environmental toxin aluminium has been linked, if tentatively, to autism spectrum disorder. Herein we have used…
Association of Tic Disorders and Enterovirus Infection
Medicine (Baltimore). 2016 Apr; 95(15): e3347. Abstract There has been growing interest in the association between infectious disease and mental disorders, but an association between enterovirus (EV) infection and tic disorders has not been sufficiently explored. Herein, we aim to investigate the association between EV infection and incidence of tic disorders in a nationwide population-based…
The Relationship between Sleep Problems, Neurobiological Alterations, Core Symptoms of Autism Spectrum Disorder, and Psychiatric Comorbidities
J. Clin. Med. 2018, 7(5) Abstract Children with Autism Spectrum Disorder (ASD) are at an increased risk for sleep disturbances, and studies indicate that between 50 and 80% of children with ASD experience sleep problems. These problems increase parental stress and adversely affect family quality of life. Studies have also suggested that sleep disturbances may…
Vitamin D Status And ADHD
Adv. Nut. 2018 Jan 1;9(1):9-20. doi: 10.1093/advances/nmx002. An association between vitamin D and attention deficit hyperactivity disorder (ADHD) has been proposed by several researchers in recent years; however, the investigations have led to inconsistent results. The present study was conducted to summarize the published observational data on the relation between vitamin D status and the…
Dysbiotic Gut Can Promote Inflammation of The Central Nervous System
Nature volume 557, pages724–728 (2018) Research published in Nature in May 2018 focuses on the influence of gut microbes on two types of cells that play a major role in the central nervous system: microglia and astrocytes. Microglia are an integral part of the body’s immune system, responsible for scavenging the CNS and getting rid of plaques,…
Link Between The Gut Microbiome And The Anti-Seizure Effects of the Ketogenic Diet
https://doi.org/10.1016/j.cell.2018.04.027 The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered by the KD and required for protection against acute electrically induced seizures and spontaneous tonic-clonic seizures in two mouse models. Mice treated with antibiotics or reared…
Can Gut Bacteria Influence Social Development?
Molecular Psychiatry volume 19, pages 146–148 (2014 The microbiota–gut–brain axis is an emerging concept in modern medicine informed by the ability of gut microbiota to alter brain and behaviour.1 Although some clinical studies have revealed altered gut microbiota composition in patients with neurodevelopmental disorders such as autism,2, 3 the specific contributions of microbiota in early…
