Journal of Neuroscience 16 July 2018, 0607-18; DOI: https://doi.org/10.1523/JNEUROSCI.0607-18.2018 ABSTRACT The growth and organization of the developing brain is known to be influenced by hormones, but little is known about whether disruption of hormones affects cortical regions, like the medial prefrontal cortex (mPFC). This region is particularly important given its involvement in executive functions and…

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European Child & Adolescent Psychiatry February 2018, Volume 27, Issue 2, pp 233–240 Abstract The aim of this study is to assess the prevalence of small intestinal bacterial overgrowth (SIBO) by hydrogen breath test in patients with autism spectrum disorders (ASD) with respect to a consistent control group. From 2011 to 2013, 310 children with ASD and…

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The Journal of Nutrition, Volume 148, Issue 6, 1 June 2018, Pages 861–867 Abstract Epidemiologic data suggest that diets rich in nuts have beneficial health effects, including reducing total and cause-specific mortality from cancer and heart disease. Although there is accumulating preclinical evidence that walnuts beneficially affect the gastrointestinal microbiota and gut and metabolic health,…

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Neurochem Res. 2015 Dec; 40(12): 2583–2599. Abstract The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular channels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system may also function to help…

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Human Antibodies, vol. 26, no. 3, pp. 165-169, 201 Abstract Autism is a neurodevelopmental disease that is manifested by a wide range of behavioural disorders. Although the aetiology of autism remains unknown it is suggested that ASD have a complex aetiology, including genetic and environmental factors, which may explain the observed different behavioural disorders in…

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JAMA Network Open. 2018;1(2):e180279 Abstract The prevalence of autism spectrum disorder (ASD) in US children has increased during the past decades. Immunologic dysfunction has recently emerged as a factor associated with ASD. Although children with ASD are more likely to have gastrointestinal disorders, little is known about the association between food allergy and ASD. Read…

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Neurosciences (Riyadh). 2016 Jul; 21(3): 252–255. Abstract New-onset psychosis in children represents a complex presenting symptom. Psychosis can be attributable to a combination of factors and etiologies, and all possible causes must be systematically examined. There is growing evidence that a proportion of psychosis/psychiatric manifestations in children may be immune-mediated, and physicians should consider this…

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Dev Med Child Neurol. 2008 May Abstract In cerebral folate deficiency syndrome, the presence of autoantibodies against the folate receptor (FR) explains decreased folate transport to the central nervous system and the clinical response to folinic acid. Autoantibody crossreactivity with milk FR from different species prompted us to test the effect of a milk-free diet.…

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https://doi.org/10.1016/j.mito.2017.12.007 Abstract Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis,…

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J Pediatr. 2018 May 8.  Objective To investigate the prospective associations between early childhood lead exposure and subsequent risk of attention deficit hyperactivity disorder (ADHD) in childhood and its potential effect modifiers. Study Design We analyzed data from 1479 mother-infant pairs (299 ADHD, 1180 neurotypical) in the Boston Birth Cohort. The child’s first blood lead…

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